Inhibitory effect of the NMDA receptor antagonist, dizocilpine (MK-801), on the development of morphine dependence.
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چکیده
منابع مشابه
the effect of using visual aids on the development of speech act of disagreement among iranian intermediate efl learners
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15 صفحه اولThe NMDA antagonist dizocilpine (MK-801) reverses haloperidol-induced movement initiation deficits.
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متن کاملThe NMDA receptor antagonist MK-801 increases morphine catalepsy and lethality.
Interactions between excitatory amino acids and opioids were examined by studying the ability of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 to affect morphine catalepsy and lethality. MK-801 (0.3 mg/kg) reduced the ED50 for morphine-induced catalepsy from approximately 30 mg/kg to less than 10 mg/kg, and reduced the LD50 for morphine from approximately 100 mg/kg t...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1996
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.21.2_135