Inhibitors of amino acids biosynthesis as antifungal agents
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چکیده
منابع مشابه
Inhibitors of 2,3-oxidosqualene lanosterol-cyclase as potential antifungal agents.
Fig. 1. StcJrol hiosynthesis squalene to lanosterol. This enzyme has been shown to hc essential f o r fungi; Sacchurornyces cerevisiue mutants lacking this key enzyme in fact require exogenous ergosterol supplementation for growth 121. Even if these early steps in sterol biosynthesis are common to mammals and fungi, the example of the allylamines. which act on squalene epoxidase 131. shows that...
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aneous and followed a reversible competitive mechanism in S/reptonivc~e.s p. and a reversible non-competitive mechanism in N . erythropo1i.s and S . wt t i t t i i t t i e . An irreversible type of inhibition was observed for 1'. lestostcrorii cholesterol oxid a se . T h e fit o f thc inhibition profile o f cyclic amines with cholesterol oxidases and AS A'-isomerases offers a fungicide screenin...
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متن کاملBiosynthesis of amino acids in Clostridium pasteurianum.
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ژورنال
عنوان ژورنال: Amino Acids
سال: 2014
ISSN: 0939-4451,1438-2199
DOI: 10.1007/s00726-014-1873-1