Inhibitor of fibrinolysis in human arterial wall
نویسندگان
چکیده
منابع مشابه
Identification of thrombin activatable fibrinolysis inhibitor (TAFI) in human platelets.
Thrombin activatable fibrinolysis inhibitor (TAFI) is a carboxypeptidase B-like proenzyme that after activation down-regulates fibrinolysis. Platelets are known to contain antifibrinolytic factors that are secreted during platelet activation. Therefore, the presence of TAFI in platelets was analyzed. TAFI was identified in platelets in a concentration of about 50 ng/1 x 109 platelets and was se...
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Introduction: Arterial stiffness is an important predictor of cardiovascular risk. Several indices have been introduced to estimate the arterial stiffness based on the changes in the brachial blood pressure. Since the substitution of the blood pressure changes in the central arteries such as carotid with the blood pressure changes in the brachial results in error in the blood...
متن کاملThrombin activatable fibrinolysis inhibitor.
Thrombin activatable fibrinolysis inhibitor (TAFI) was discovered two decades ago as a consequence of the identification of an unstable carboxypeptidase (CPU), which was formed upon thrombin activation of the respective pro-enzyme (proCPU). The antifibrinolytic function of the activated form (TAFIa, CPU) is directly linked to its capacity to remove C-terminal lysines from the surface of the fib...
متن کاملVascular release of plasminogen activator inhibitor-1 impairs fibrinolysis during acute arterial thrombosis in mice.
The role of plasminogen activator inhibitor-1 (PAI-1) in the plasma, blood platelets, and vessel wall during acute arterial thrombus formation was investigated in gene-deficient mice. Photochemically induced thrombosis in the carotid artery was analyzed via transillumination. In comparison to thrombosis in C57BL/6J wild-type (wt) mice (113 +/- 19 x 10(6) arbitrary light units [AU] n = 15, mean ...
متن کاملThrombin activatable fibrinolysis inhibitor and other hemostatic parameters in patients with essential arterial hypertension.
INTRODUCTION Hypertension is associated with hemostatic abnormalities and endothelial dysfunction. thrombin activatable fibrinolysis inhibitor (TAFI) is a glycoprotein linking coagulation and fibrinolysis. Objectives. We evaluated TAFI concentrations in patients with essential hypertension in relation to blood pressure. Additionally, we studied TAFI activator, thrombin activity (thrombin-antith...
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ژورنال
عنوان ژورنال: Blood & Vessel
سال: 1980
ISSN: 0386-9717,1884-2372
DOI: 10.2491/jjsth1970.11.683