Inhibition of sperm motility in male macaques with EP055, a potential non-hormonal male contraceptive

Male sperm storage compromises sperm motility in guppies.

Sperm senescence can have important evolutionary implications due to its deleterious effects on sperm quality and offspring performance. Consequently, it has been argued that polyandry (female multiple mating) may facilitate the selection of younger, and therefore competitively superior, sperm when ejaculates from multiple males compete for fertilization. Surprisingly, however, unequivocal evid...

Does ethnicity matter in male hormonal contraceptive efficacy?

The development of male hormonal contraception has progressed significantly during the last three decades. The ultimate goal is to produce an effective, safe and reversible male method of contraception that are within reach of and can be used by all men globally. This review aims to outline the recent developments in male hormonal contraception with special emphasis on how ethnicity influences ...

Hormonal regulation of spermatogenesis in primates and man: insights for development of the male hormonal contraceptive.

A better understanding of the hormonal regulation of spermatogenesis may provide new avenues for management of human infertility, and development of safe and reversible contraceptives. Although much basic work must be conducted in lower mammals, primarily rodents, concepts must, at some stage, be tested for their relevance to humans. In this review, we will draw together existing data in humans...

P-14: The Effects of Depression on Reduced Sperm Motility in Male Rats

Background: Infertility is a problem for 15 to 30% couples. Male infertility may be a result of insufficient number of sperms and poor motility. Spermatozoon consists of a head,midpiece and tail. The long tail consist micro-tubules that from part of the propulsion system of the spermatozoon. Motility of sperm is the result of relation between ATP,micro-tubules and dynein. Depression is one of t...

Non-systemic, Non-hormonal Forms of Male Contraceptives