Inhibition of Simian Virus 40 DNA Synthesis by Frog Virus 3
نویسندگان
چکیده
منابع مشابه
DNA synthesis by partially purified replicating simian virus 40 chromosomes.
We have partially purified replicating simian virus 40 (SV40) chromosomes in a form which allows continued DNA synthesis in vitro. We first prepare a soluble DNA-synthesizing system from SV40-infected monkey cells and then sediment the components through a neutral sucrose gradient of extremely low ionic strength. Replicating SV40 chromosomes isolated from such gradients are capable of continuin...
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Recently, the antiviral activity of kanamycin derivatives against influenza and herpes simplex virus has been reported1~3). The mechanism of antiviral action of these agents is not well understood. In this report, the mechanism of antiviral effect of 1-N-eicosanoyl-3"-N-(trifluoroacetyl)kanamycin (ETK), one of these agents, was studied. We have tried to test the effect of ETK on simian virus 40...
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The E46(+) strain of Adenovirus 7 is a mixed-virus population containing defective Adenoviurs 7-SV40 hybrid particles and helper, nonhybrid Adenovirus 7 particles. We have applied electron microscopic mapping techniques to obtain a physical map of the genome of the hybrid particles present in E46(+)PL1, a substrain of E46(+) derived from a single two-hit plaque. DNA molecules extracted from pur...
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The synthesis of tumor and viral antigens after infection of an established line of cynomolgus monkey kidney cells with simian virus 40 (SV40) was compared in cells previously infected with Yaba virus and in cells not preinfected. SV40 failed to induce synthesis of tumor or viral antigens in cells preinfected with Yaba virus. The inhibitory state in preinfected cells was shown to develop sequen...
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The early simian virus 40 (SV40) gene product, large tumor (T) antigen, is responsible for the initiation of viral DNA replication and the autoregulation of early gene expression through direct protein-DNA interactions. We investigated the role of T antigen in late viral gene expression, independent of its function in amplifying templates through DNA replication. SV40 DNA was transfected into B...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1974
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-23-3-335