Inhibition of Semaphorin As a Novel Strategy for Therapeutic Angiogenesis

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Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis.

RATIONALE The axon-guiding molecules known as semaphorins and their receptors (plexins) regulate the vascular pattern and play an important role in the development of vascular network during embryogenesis. Semaphorin (Sema)3E is one of the class 3 semaphorins, and plexinD1 is known to be its receptor. Although these molecules have a role in embryonic vascular development, it remains unclear whe...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 2010

ISSN: 0009-7330,1524-4571

DOI: 10.1161/circresaha.109.210815