Inhibition of pre-mRNA splicing by 5-fluoro-, 5-chloro-, and 5-bromouridine
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چکیده
منابع مشابه
1-(5-Chloro-6-fluoro-1,3-benzothiazol-2-yl)hydrazine
In the title compound, C(7)H(5)ClFN(3)S, the 1,3-benzothia-zole ring system is nearly planar (r.m.s. deviation = 0.023 Å). In the crystal, mol-ecules are linked via inter-molecular N-H⋯N hydrogen bonds into a two-dimensional network parallel to (100).
متن کاملTrans-complementation of the second step of pre-mRNA splicing by exogenous 5' exons.
During splicing of nuclear pre-mRNAs, the first step liberates the 5' exon (exon 1) and yields a lariat intron-3'exon (intron-exon 2) intermediate. The second step results in exon ligation. Previous results indicated that severe truncations of the 5' exon of the actin pre-mRNA result in a block to the second splicing step in vitro in yeast extracts, leading to an accumulation of intron-exon 2 l...
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s of the American Chemical Society Meeting,Miami,Fla.,April 1957, p. 3c. 13. Hampton, E. G., and Eidinoff, M. L. Administration of 5-Iododeoxyuridine-I'@†̃in the Mouse and Rat. Cancer Res., 21:345—352,1961.14. Heidelberger,C., Birnie, G. D., Boohar, J., and Wentland,D.Fluorinated Pynimidines, XX. Inhibition of the Nucleoside Phosphorylase Cleavage of 5-Flu...
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Background & Aims: Drugs are highly active due to their many functional groups and can be easily destroyed by stomach acid and excreted before reaching target tissue. Thus, by encapsulating, a sheath is placed around drug to reduce reactivity of the drug due to stereo electronic resonance with nanotube and consequently drug stays longer in body. As a result, you can consume a smaller dose of dr...
متن کامل5-Chloro-2-nitrophenol
The asymmetric unit of the title compound, C(6)H(4)ClNO(3), contains two independent mol-ecules in which the dihedral angles between the benzene ring and the nitro groups are 2.5 (1) and 8.5 (1)°. Intra-molecular O-H⋯O hydrogen bonds involving the hy-droxy and nitro substituents result in the formation of S(6) six-membered rings. In the crystal, O-H⋯O, O-H⋯Cl and C-H⋯O hydrogen bonds together w...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)47285-2