Inhibition of Porphyromonas gingivalis Biofilm by Oxantel

Inhibition of Porphyromonas gingivalis biofilm by oxantel.

Porphyromonas gingivalis is a major pathogen of chronic periodontitis and exists in a biofilm on the surface of the tooth root. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms at concentrations below its MIC against planktonic cells. Oxantel was more effective against P. gingivali...

Stimulation of Fusobacterium nucleatum biofilm formation by Porphyromonas gingivalis.

BACKGROUND/AIMS Bacterial infection is a major cause of periapical periodontitis. Eradication of these microorganisms from apical lesions is essential to the success of endodontic treatment. The aim of this study was to clarify the molecular interaction between Fusobacterium nucleatum, Porphyromonas gingivalis and other microorganisms associated with periapical periodontitis. METHODS Microorg...

Porphyromonas gingivalis Formation by Role of Polyphosphate Kinase in Biofilm

Involvement of respiratory chain in biofilm formation in porphyromonas gingivalis.

Introduction Porphyromonas gingivalis (P.gingivalis) is a gram-negative strict-anaerobe bacterium and constitutes one of the main pathogen responsible for periodontal diseases (2). Periodontal diseases are chronic inflammatory infections induced by bacteria organised in biofilm. More than 500 bacteria species take part in this biofilm including P. gingivalis (3). Although strict-anaerobe, P. gi...

Click scaffolds for the inhibition of Porphyromonas gingivalis and Streptococcus gordonii biofilm formation

CLICK SCAFFOLDS FOR THE INHIBITION OF PORPHYROMONAS GINGIVALIS AND STREPTOCOCCUS GORDONll BIOFILM FORMATION Catherine M. Loner April 18,2012 Periodontitis and its systemic sequelae remain a major public health problem and developing a cost-efficient therapy will benefit healthcare worldwide. Adherence of Porphyromonas gingivalis to Streptococcus gordonii facilitates colonization ofthe oral cavi...