Inhibition of peroxisomal degradation by 3-methyladenine (3MA) in primary cultures of rat hepatocytes
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چکیده
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Metabolism of ochratoxin A by primary cultures of rat hepatocytes.
Association of ochratoxin A with cultured rat hepatocytes occurs at 4 degrees C, and the saturation level in the medium is 0.3 mM ochratoxin A, with maximal binding after 60 min. At 37 degrees C the level of cell-associated ochratoxin A increased up to 6 h and remained at 2 nmol of toxin per mg of cell protein for 30 h. With increasing concentrations of ochratoxin A, increasing amounts of the t...
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Regulation of rat hepatic 3 alpha-hydroxysteroid dehydrogenase in vivo and in primary cultures of rat hepatocytes.
In the bile acid biosynthetic pathways of humans and the rat, hepatic 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSDH) catalyzes the stereospecific reduction of the 3-oxo group of bile acid precursors. In addition, 3 alpha-HSDH may serve to shuttle bile acids from sinusoidal to apical (cannalicular) membranes of the rat hepatocyte. The objective of the present study was to define the molecul...
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ژورنال
عنوان ژورنال: The Anatomical Record
سال: 1997
ISSN: 0003-276X,1097-0185
DOI: 10.1002/(sici)1097-0185(199704)247:4<449::aid-ar2>3.0.co;2-m