Inhibition of PD-L1 and tumor growth in triple-negative breast cancer using a magnetic nanovector with microRNA34a

Abstract Background Clinical applications of RNA interference for cancer treatment and immune therapy require the development simultaneous imaging systems microRNA. This research was performed to fabricate miRNA34a-loaded magnetic nanoparticles investigate its anticancer effects against triple-negative breast (TNBC) in mice model. Results Using two types polymers improve their water dispersibility gene delivery, iron oxide were prepared delivery miRNA34a. The delivered TNBC cells, efficacy evaluated vitro vivo. Delivery miRNA34a reduced cell migration decreased expression PD-L1 at mRNA protein levels. In animal experiments, tumor growth, immunostaining algorithmic analysis confirmed decrease expression. Conclusion study is first modulate by delivering with nanoparticles, results suggest that can be effectively using has potential as a molecular contrast agent.