Inhibition of neointima formation by tranilast in pig coronary arteries after balloon angioplasty and stent implantation
نویسندگان
چکیده
منابع مشابه
Inhibition of neointima formation by tranilast in pig coronary arteries after balloon angioplasty and stent implantation.
OBJECTIVES We evaluated the effect of orally administered tranilast, N-(3,4-dimethoxycinnamoyl) anthranilic acid, on histologic and histomorphometric changes after angioplasty or stent implantation in pig coronary arteries. BACKGROUND Tranilast, which has antikeloid and antiallergic properties and therefore may modulate the fibrotic and inflammatory tissue responses to angioplasty and stentin...
متن کاملCirculating monocytes and in-stent neointima after coronary stent implantation.
OBJECTIVES The aim of this study was to investigate the relationship between circulating monocytes and in-stent neointimal volume at six-month follow-up. BACKGROUND In-stent neointimal hyperplasia is the main contributing factor to in-stent restenosis. There is increasing evidence that white blood cells (WBCs), especially monocytes, play a central role in restenosis after stent implantation. ...
متن کاملResponse of very small (2 mm) porcine coronary arteries to balloon angioplasty and stent implantation.
OBJECTIVE To investigate the response of very small coronary arteries to stent deployment and balloon angioplasty. SETTING Normal porcine coronary arteries. METHODS 24 pigs underwent intervention to two main coronary arteries, in segments 2.0 mm in diameter, with balloons whose diameter was 2.5 mm at standard pressure. Twelve arteries received a BiodivYsio small vessel (SV) stent; 12 an NIR...
متن کاملIntracoronary -Radiation Exacerbates Long-Term Neointima Formation in Balloon-Injured Pig Coronary Arteries
Background—Long-term biological effects of ionizing radiation on coronary arteries remain poorly defined. We examined late arterial responses 6 months after balloon angioplasty and -radiation in normal pig coronary arteries. Methods and Results—Coronary arteries of 25 adult pigs were randomized to receive 20 Gy (n 8) or 30 Gy (n 9) of Re -radiation or sham radiation (n 8) immediately after ball...
متن کاملIntracoronary beta-radiation exacerbates long-term neointima formation in balloon-injured pig coronary arteries.
BACKGROUND Long-term biological effects of ionizing radiation on coronary arteries remain poorly defined. We examined late arterial responses 6 months after balloon angioplasty and beta-radiation in normal pig coronary arteries. METHODS AND RESULTS Coronary arteries of 25 adult pigs were randomized to receive 20 Gy (n=8) or 30 Gy (n=9) of (186)Re beta-radiation or sham radiation (n=8) immedia...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2000
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(00)00528-3