Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids
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چکیده
منابع مشابه
Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids.
The alkaloids from Chelidonium majus L. which had a significant inhibitory effect in mitochondrial respiration were those which contain a positive charge due to a quaternary nitrogen atom, i.e., chelerythrine, sanguinarine, berberine and coptisine, both with malate+glutamate or with succinate as substrates. When malate+glutamate was used as substrate, chelerythrine and berberine, which contain ...
متن کاملChelidonium majus-Induced Acute Hepatitis
Medicinal herbs, defined as preparations concocted by an unauthorized layperson [1], are used widely in Asian countries because they are easily available and are believed to be harmless. Despite this belief, hepatitis, and even fulminant hepatitis, associated with medicinal herbs has been reported. According to previous reports, drug-induced liver injury accounts for 2~40% of all liver injury [...
متن کاملAntibacterial alkaloids from chelidonium majus linn (papaveraceae) against clinical isolates of methicillin-resistant Staphylococcus aureus.
PURPOSE This study describes the antibacterial effect of extracts and compounds isolated from the aerial part of Chelidonium majus Linn. (Papaveraceae) acting against clinical strains of methicillin-resistant Staphylococcus aureus (MRSA). METHODS The activities were evaluated by using the macrobroth dilution method and reported as the MICs/MBCs. RESULTS Bioassay-guided fractionation of the ...
متن کاملCapillary electrophoresis with LED-induced native fluorescence detection for determination of isoquinoline alkaloids and their cytotoxicity in extracts of Chelidonium majus L.
In this study, we introduced a simple and sensitive method of capillary electrophoresis with ultraviolet light-emitting diode-induced native fluorescence (UV-LEDIF) detection for the determination of isoquinoline alkaloids in extracts of Chelidonium majus L. Samples were extracted with acidic methanol and the extracts were directly analysed by CE. Simultaneous determination of protopine, chelid...
متن کاملChelidonium majus--an integrative review: traditional knowledge versus modern findings.
Chelidonium majus L. (family Papaveraceae), or greater celandine, is an important plant in western phytotherapy and in traditional Chinese medicine. Crude extracts of C. majus as well as purified compounds derived from it exhibit a broad spectrum of biological activities (antiinflammatory, antimicrobial, antitumoral, analgesic, hepatoprotective) that support some of the traditional uses of C. m...
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ژورنال
عنوان ژورنال: Toxicology Letters
سال: 2003
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2003.09.007