Inhibition of Hydrogen Evolution in Aluminium-phosphate Refractory Binders

Do oral aluminium phosphate binders cause accumulation of aluminium to toxic levels?

BACKGROUND Aluminium (Al) toxicity was frequent in the 1980s in patients ingesting Al containing phosphate binders (Alucaps) whilst having HD using water potentially contaminated with Al. The aim of this study was to determine the risk of Al toxicity in HD patients receiving Alucaps but never exposed to contaminated dialysate water. METHODS HD patients only treated with Reverse Osmosis(RO) tr...

Does oral aluminium cause toxicity? Do oral aluminium phosphate binders cause accumulation of aluminium to toxic levels?

Background We wished to determine the risk of Al toxicity in HD patients receiving Alucaps but never exposed to contaminated dialysate water. Methods HD patients only treated with Reverse Osmosis(RO) treated dialysis water with either current or past exposure to Alucaps were given standardised DFO tests. Post-DFO serum Al level >3.0μmol/L was defined to indicate toxic loads based on previous bo...

Inhibition of Human Erythrocyte Glucose 6-Phosphate Dehydrogenase by Cadmium, Nickel and Aluminium

Do aluminium-based phosphate binders continue to have a role in contemporary nephrology practice?

BACKGROUND Aluminium-containing phosphate binders have long been used for treatment of hyperphosphatemia in dialysis patients. Their safety became controversial in the early 1980's after reports of aluminium related neurological and bone disease began to appear. Available historical evidence however, suggests that neurological toxicity may have primarily been caused by excessive exposure to alu...

Effects of phosphate binders in moderate CKD.

Some propose using phosphate binders in the CKD population given the association between higher levels of phosphorus and mortality, but their safety and efficacy in this population are not well understood. Here, we aimed to determine the effects of phosphate binders on parameters of mineral metabolism and vascular calcification among patients with moderate to advanced CKD. We randomly assigned ...