Inhibition of human lung cancer cell growth by angiotensin-(1-7)

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Inhibition of human lung cancer cell growth by angiotensin-(1-7).

Angiotensin-(1-7) [Ang-(1-7)] is an endogenous peptide hormone of the renin-angiotensin system with vasodilator and anti-proliferative properties. Human adenocarcinoma SK-LU-1 and A549 cells as well as non-small lung cancer SK-MES-1 cells were treated with serum in the presence and absence of Ang-(1-7), to determine whether Ang-(1-7) inhibits the growth of lung cancer cells. Ang-(1-7) caused a ...

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Fragrant species of the genus Salvia have been attributed many medicinal properties, which include anticancer activity. In the present study, cytotoxic properties of total methanol extract of Salvia chloroleuca Rech. f. & Aellen and its fractions were investigated on MCF-7, a breast carcinoma cell line. Malignant and non-malignant cells were cultured in RPMI medium and incubated with different ...

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Molecular mechanisms of inhibition of vascular growth by angiotensin-(1-7).

Angiotensin (Ang) peptides play a critical role in regulating vascular reactivity and structure. We showed that Ang-(1-7) reduced smooth muscle growth after vascular injury and attenuated the proliferation of vascular smooth muscle cells (VSMCs). This study investigated the molecular mechanisms of the antiproliferative effects of Ang-(1-7) in cultured rat aortic VSMCs. Ang-(1-7) caused a dose-d...

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growth inhibition and apoptosis induction of salvia chloroleuca on mcf-7 breast cancer cell line

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ژورنال

عنوان ژورنال: Carcinogenesis

سال: 2004

ISSN: 1460-2180

DOI: 10.1093/carcin/bgh236