Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells

Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells.

Recently, it was demonstrated that lineage-committed oligodendrocyte precursor cells (OPCs) can be converted to multipotent neural stem-like cells, capable of generating both neurons and glia after exposure to bone morphogenetic proteins. In an effort to understand and control the developmental plasticity of OPCs, we developed a high-throughput screen to identify novel chemical inducers of OPC ...

Inhibition of Histone Deacetylase Activity

Histone deacetylase activity is necessary for oligodendrocyte lineage progression.

Gene expression can be modulated by chromatin changes induced by histone acetylation and deacetylation. Acetylation of histone lysine residues by acetyltransferases is associated with transcriptionally active chromatin, whereas the removal of acetyl groups by histone deacetylases (HDACs) correlates with repressed chromatin. Recent evidence has shown that histone deacetylation is responsible for...

Inhibition of axon growth by oligodendrocyte precursor cells.

The glial scar that forms at the site of injury is thought to be a biochemical and physical barrier to successful regeneration, although the molecules responsible for this barrier function are not well understood. Glia scars contain large numbers of oligodendrocyte precursor cells (OPCs) and these cells can produce several different growth-inhibitory chondroitin sulfate proteoglycans (CSPGs), i...

Inhibition of Histone Deacetylase Suppresses