Inhibition of G-protein betagamma-subunit functions by phosducin-like protein.
نویسندگان
چکیده
منابع مشابه
Inhibition of G-protein 13y-subunit functions by phosducin-like protein
Phosducin is a cytosolic protein predominantly expressed in the retina and the pineal gland that can interact with the fty subunits of guanine nucleotide binding proteins (G proteins) and thereby may regulate transmembrane signaling. A cDNA encoding a phosducin-like protein (PhLP) has recently been isolated from rat brain [Miles, M. F., Barhite, S., Sganga, M. & Elliott, M. (1993) Proc. Nati. A...
متن کاملRegulation of angiotensin II-induced G protein signaling by phosducin-like protein.
Phosducin-like protein (PhLP) is a broadly expressed member of the phosducin (Pd) family of G protein betagamma subunit (Gbetagamma)-binding proteins. Though PhLP has been shown to bind Gbetagamma in vitro, little is known about its physiological function. In the present study, the effect of PhLP on angiotensin II (Ang II) signaling was measured in Chinese hamster ovary cells expressing the typ...
متن کاملFidelity of G protein b-subunit association by the G protein g-subunit-like domains of RGS6, RGS7, and RGS11
Several regulators of G protein signaling (RGS) proteins contain a G protein g-subunit-like (GGL) domain, which, as we have shown, binds to Gb5 subunits. Here, we extend our original findings by describing another GGLdomain-containing RGS, human RGS6. When RGS6 is coexpressed with different Gb subunits, only RGS6 and Gb5 interact. The expression of mRNA for RGS6 and Gb5 in human tissues overlap...
متن کاملPhosducin is a ubiquitous G-protein regulator.
Phosducin is a 33-kDa cytosolic regulator of G-protein-mediated signaling that has previously been thought to be specific for retina and pineal gland. In this study, we show widespread tissue distribution of phosducin by the amplification of its cDNA and the detection of two different transcripts in Northern analyses in liver, lung, heart, brain, and retina. On the protein level, phosducin coul...
متن کاملPhosducin and phosducin-like protein attenuate G-protein-coupled receptor-mediated inhibition of voltage-gated calcium channels in rat sympathetic neurons.
Phosducin (PDC) has been shown in structural and biochemical experiments to bind the Gbetagamma subunit of heterotrimeric G-proteins. A proposed function of PDC and phosducin-like protein (PDCL) is the sequestration of "free" Gbetagamma from the plasma membrane, thereby terminating signaling by Gbetagamma. The functional impact of heterologously expressed PDC and PDCL on N-type calcium channel ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.5.2100