Inhibition of Escherichia coli isoleucine biosynthesis by isoleucine tetrazole
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چکیده
منابع مشابه
Isoleucine and Valine Metabolism of Escherichia Coli
In the preceding publication (1) mention has been made of the syntrophism existing between the mutant strains llA16 and 2OA19 of Escherichia COG. These mutants, requiring isoleucine and isoleucine plus valine respectively, were able to grow together on a minimal agar plate, free of amino acids, which would not support the growth of either mutant alone. The nature of this syntrophism forms the s...
متن کاملBiosynthesis of Valine and Isoleucine
The isotope studies of Strassman et al. (3, 4) first implicated cu-acetolactate and cu-aceto-cY-hydroxybutyrate as biosynthetic precursors of valine and isoleucine, respectively. The observed accumulation of acetolactate by Escherichia coli (5, 6) and of the decarboxylation products of acetolactate and acetohydroxybutyrate by Neurospora crassa (7) when mutants of these organisms are grown with ...
متن کاملBiosynthesis of Valine and Isoleucine
Evidence published in recent years has shown that the biosynthesis of valine and isoleucine proceeds by a similar sequence of reactions (24). Fig. 1 depicts the reactions considered to be involved. In this report only Reactions II, III, and IV will be considered. Reaction II, the isomerization of the Lu-hydroxy$keto acid (ac-acetolactate for valine biosynthesis and a-aceto-a-hydroxybutyrate for...
متن کاملIsoleucine and valine metabolism in Escherichia coli. V. Antagonism between isoleucine and valine.
The influence of the relative concentrations of amino acids in culture media on the growth of microorganisms was first brought to the attention of microbiologists by Gladstone (1939). He observed that isoleucine, valine, or leucine added singly to a synthetic medium inhibited the growth of the anthrax bacillus whereas a mixture of the three stimulated growth. Although Gladstone was unable at th...
متن کاملInterference with valine and isoleucine biosynthesis by cyclic hydroxamic acids.
Hogg, Robert W. (University of Illinois, Urbana), Chitra S. Biswas, and Harry P. Broquist. Interference with valine and isoleucine biosynthesis by cyclic hydroxamic acids. J. Bacteriol. 90:1265-1270. 1965.-The introduction of a hydroxyl group in a number of common barbiturates, a substitution which converts these compounds to cyclic hydroxamic acids, gives rise to compounds which inhibit growth...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1975
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.123.3.862-870.1975