Inhibition of equine herpesvirus type 1 subtype 1-induced ribonucleotide reductase by the nonapeptide YAGAVVNDL
نویسندگان
چکیده
منابع مشابه
Herpes Simplex Type 1 Ribonucleotide Reductase
Several known inhibitors of mammalian ribonucleotide reductase were studied for their interactions with herpes simplex virus type 1 (HSV-1) ribonucleotide reductase. MAIQ (4-methyl-5-amino-l-formylisoquinoline thiosemicarbazone) produced apparent inactivation of HSV-1 ribonucleotide reductase. Only catalytically cycling, not resting, enzyme could be inactivated. Double reciprocal replots of the...
متن کاملRibonucleotide Reductase Induced by Herpes Simplex Type
The ribonucleotide reductase induced by herpes simplex virus type 1 (HSV-1) was purified in high yield from serum-starved baby hamster kidney (BHK-21) cells infected with HSV-1 (strain H-29). The enzyme preparation was essentially free of both eucaryotic ribonucleotide reductase and contaminating enzymes that could cause significant depletion f substrates. The HSV-l-induced enzyme was assayed i...
متن کاملInhibition of ribonucleotide reductase activity by IC202C.
suppresses DNAsynthesis by inhibition of ribonucleotide reductase.4) Ribonucleotide reductase plays an essential role in DNAsynthesis in most organisms.5) The enzyme is a nonheme iron-containing protein, which requires ATPand Mg2+ as co factors. As previously reported that IC202C has art affinity against Fe(III) ion,3) we have examined the effect of IC202C on ribonucleotide reductase activity u...
متن کاملEquine herpesvirus-1 consensus statement.
Equine herpesvirus-1 is a highly prevalent and frequently pathogenic infection of equids. The most serious clinical consequences of infection are abortion and equine herpesvirus myeloencephalopathy (EHM). In recent years, there has been an apparent increase in the incidence of EHM in North America, with serious consequences for horses and the horse industry. This consensus statement draws toget...
متن کاملTitle : A retrospective study on equine herpesvirus type - 1 associated
Diagnosis of equine herpesvirus-1 associated myeloencephalopathy (EHM) can be troublesome, but early recognition and knowledge of risk factors are essential for prevention and control. The objectives for this study are to 1) describe EHM in France, 2) improve clinical recognition, 3) identify risk factors. Through epidemiosurveillance of acute neurological cases (all considered to be potentiall...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1990
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-71-6-1373