Inhibition of endothelial-bound angiotensin converting enzyme, in vivo

Angiotensin Converting Enzyme in Sarcoidosis

Inhibition of Angiotensin-Converting Enzyme Reduces Cerebral Infarction Size in Experimental-Induced Focal Cerebral Ischemia in the Rat

Background: The role of Renin Angiotensin System (RAS) in ischemic/reperfusion (I/R) injuries is not fully elucidated. Furthermore, it is not clear whether inhibition of RAS by Angiotensin-Converting Enzyme (ACE) inhibitors has beneficial effects in terms of protecting the brain from I/R injuries. In this study enalapril is used as an ACE inhibitor to evaluate the role of RAS in I/R injuries in...

Role of Tissue Angiotensin-Converting Enzyme Inhibition

Background Chronic treatment with high doses of angiotensin-converting enzyme (ACE) inhibitors prolongs survival after myocardial infarction. Since the plasma reninangiotensin system (RAS) is not consistently activated in the chronic phase after myocardial infarction, the beneficial effects of ACE inhibition have been attributed, in part, to inhibition of an activated tissue RAS. However, a rel...

Effects of Chronic Angiotensin Converting Enzyme Inhibition

Background. Previous studies have shown that global left ventricular function is depressed after myocardial infarction. However, little is known about the effects of myocardial infarction on contractility and the passive-elastic properties of residual myocardium. Methods and Results. We evaluated isometric function and passive myocardial stiffness in isolated, noninfarcted left ventricular papi...

Respiratory effects of angiotensin converting enzyme inhibition.

Angiotensin converting enzyme (ACE) inhibitors have been available for the treatment of hypertension and heart failure for several years. This class of drugs is generally well accepted by the patient (1), but an unusual, infrequent, and troublesome side-effect, cough, has become apparent. This article reviews this side-effect and also the possibility of other respiratory effects of ACE inhibition.