Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons
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چکیده
منابع مشابه
Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons
Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of disorders, in particular major depression and neuropathic pain. In the 1970s the ability of tricyclic antidepressants to inhibit acid sphingomyelinase (ASM) was discovered. The enzyme ASM catalyzes the hydrolysis of sphingomyelin to ceramide. ASM and ceramide were shown to play a crucial role in a wide r...
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INTRODUCTION Psychiatrists have been very reluctant to accept the idea that depressions, which they know so well, may be caused by allergies to common environmental molecules such as foods, airborne particles, and chemicals in water. When patients were depressed and anxious, and at the same time suffered from diseases accepted as allergic, psychosomatic explanations were used. This usually mean...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2014
ISSN: 1664-042X
DOI: 10.3389/fphys.2014.00331