منابع مشابه
Cell Death Inhibition Keeping Caspases in Check
Upon viral infection, cells commit suicide and die by Successful implosion of a building depends on the preapoptosis as an altruistic defense mechanism to benefit cise and timely detonation of explosives. If a cell underthe organism. Several viruses have built into their gegoing apoptosis is analogous to an imploding building, nome apoptosis-inhibiting arsenal, including proteins then the explo...
متن کاملInhibition of caspases prevents ototoxic and ongoing hair cell death.
Sensory hair cells die after acoustic trauma or ototoxic insults, but the signal transduction pathways that mediate hair cell death are not known. Here we identify several important signaling events that regulate the death of vestibular hair cells. Chick utricles were cultured in media supplemented with the ototoxic antibiotic neomycin and selected pharmacological agents that influence signalin...
متن کاملViral modulation of cell death by inhibition of caspases.
Caspases are key effectors of the apoptotic process. Some of them play important roles in the immune system, being involved in the proteolytic maturation of the key cytokines, including interleukin 1beta (IL-1beta) and IL-18. The latter directs the production of interferon gamma (IFN-gamma). Among pathogens, particularly viruses express various modulators of caspases that inhibit their activity...
متن کاملCaspases
U ncontrolled lymphoproliferation is a characteristic feature of lymphomas and leukemias. Nonmalignant lym-phoproliferative diseases are also observed in humans as well as in lpr (lymphoproliferation) and gld (generalized lymphad-enopathy) mice. The discoveries that spontaneous mutations of Fas (APO-1/CD95) or its ligand (FasL) were associated with the lpr and gld phenotypes led to a satisfying...
متن کاملDeath without caspases, caspases without death.
Apoptosis is a conserved cell-death process displaying characteristic morphological and molecular changes including activation of caspase proteases. Recent work challenges the accepted roles of these proteases. New investigations in mice and the nematode Caenorhabditis elegans suggest that there could be caspase-independent pathways leading to cell death. In addition, another type of cell death...
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ژورنال
عنوان ژورنال: médecine/sciences
سال: 2020
ISSN: 0767-0974,1958-5381
DOI: 10.1051/medsci/2020222