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Inhibiting poly(ADP-ribosylation) improves axon regeneration
The ability of a neuron to regenerate its axon after injury depends in part on its intrinsic regenerative potential. Here, we identify novel intrinsic regulators of axon regeneration: poly(ADP-ribose) glycohodrolases (PARGs) and poly(ADP-ribose) polymerases (PARPs). PARGs, which remove poly(ADP-ribose) from proteins, act in injured C. elegans GABA motor neurons to enhance axon regeneration. PAR...
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ژورنال
عنوان ژورنال: Neurosurgery
سال: 2010
ISSN: 0148-396X,1524-4040
DOI: 10.1227/01.neu.0000367835.52270.8e