منابع مشابه
Inherited Breast Cancer
During an eight-year period (January 1991– anuary 1999) a total of 11,200 women were xamined at the breast out-patient Department of he University Hospital. Of these, 7,750 were registered for the first time and 3,450 repeated their visit for different reasons. Of the 7,750 women, breast cancer was diagnosed in 261, who were treated appropriately. Out of the 261 breast cancer patients 9 (3.44%)...
متن کاملGene expression in inherited breast cancer.
Large proportions of hereditary breast cancers are due to mutations in the two breast cancer susceptibility genes BRCA1 and BRCA2. Considerable effort has gone into studying the function(s) of these tumor suppressor genes, both in attempts to better understand why individuals with these inherited mutations acquire breast (and ovarian) cancer and to potentially develop better treatment strategie...
متن کاملMutation-Specific Survival of Inherited Breast Cancer
P. Møller, Å. Borg, G. Evans, N. Haites, C.M. Steel, H. Vasen, H. Gregory, S. Hodgson, J. Apold, F. Lalloo, L. Mæhle, E. Anderson, K. Heimdal and the Biomed 2 Demonstration Programme on Inherited Breast Cancer Unit of Medical Genetics, The Norwegian Radium Hospital, N-0310 Oslo, Norway University of Lund, Sweden St. Mary’s Hospital, Manchester, UK Aberdeen University Medical School, Aberdeen, U...
متن کاملPolygenic inherited predisposition to breast cancer.
The known breast cancer predisposing genes account for only about 20% of inherited susceptibility. Epidemiological analyses suggest that much of the remaining 80% is explained by the combined effect of many individually weak genetic variants, rather than by further rare, highly penetrant mutations. In the near term, identification of variants may indicate new pathways or mechanisms in breast ca...
متن کاملManagement of an inherited predisposition to breast cancer.
Copyright © 2007 Massachusetts Medical Society. A healthy 33-year-old woman comes to establish care. She reports no breast symptoms, her age at menarche was 14, and she has no children. She notes a family history of early-onset breast cancer in her sister (whose condition was diagnosed at the age of 35 years and who is alive at 39 years), mother (diagnosed at 37 years and alive at 60 years), an...
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ژورنال
عنوان ژورنال: Disease Markers
سال: 1999
ISSN: 0278-0240,1875-8630
DOI: 10.1155/1999/289017