منابع مشابه
Discovering Protein-based Inheritance through Yeast Genetics
I will describe here the way in which I was able to discover that yeast has prions (infectious proteins), proteins that are the carriers of genetic information, and thus are acting as genes (1). This startling finding involved inventing new genetic approaches, but was possible because of my particular background and interests. Our work has broadened the 'prion' concept, originally thought to be...
متن کاملYeast prions: Inheritance by seeded protein polymerization?
The discovery that RNA enzymes — ribozymes — can fulfill a function previously thought to be the exclusive province of proteins has had far-reaching implications. It has recently become apparent that certain proteins may have the ability to transmit information and to self-replicate, functions normally associated with nucleic acids. The first self-replicating entity proposed to be ‘protein-only...
متن کاملEnsuring that yeast cells get their inheritance
A long with its DNA, a fungal cell might also hand down nuclear pore complexes (NPCs) to its offspring. A nuclear pore protein paves the way for the complexes to move from mother cell to daughter, Makio et al. and Colombi et al. reveal (1, 2). Researchers think that vertebrate cells don’t transfer intact NPCs to their progeny. The roughly 30 proteins, or nucleoporins, that make up a pore comple...
متن کاملRole of genetic polymorphisms in transgenerational inheritance in budding yeast
We studied the effect of single nucleotide polymorphisms (SNPs) on transgenerational inheritance of yeast segregants that were derived from a cross between a laboratory strain and a wild strain of Saccharomyces cerevisiae. We compared segregants with high minor allele content (MAC) relative to those with less and found a more dramatic shortening of the lag phase length for the high MAC group in...
متن کاملTemperature-sensitive yeast mutants defective in mitochondrial inheritance
The distribution of mitochondria to daughter cells is an essential feature of mitotic cell growth, yet the molecular mechanisms facilitating this mitochondrial inheritance are unknown. We have isolated mutants of Saccharomyces cerevisiae that are temperature-sensitive for the transfer of mitochondria into a growing bud. Two of these mutants contain single, recessive, nuclear mutations, mdm1 and...
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ژورنال
عنوان ژورنال: Journal of the Institute of Brewing
سال: 1947
ISSN: 0046-9750
DOI: 10.1002/j.2050-0416.1947.tb01311.x