منابع مشابه
Growth of vaccinia and variola viruses in the one-day-old fertile hen's egg.
The cultivation of viruses in fertile hen's eggs has been widely utilized, providing many advantages for virological studies, since the pioneering work of Woodruff and Goodpasture (1931). In most of such works, however, eggs more than 5 days old have been used. Recently, Yoshino (1956) described a technique for experimental infection of the 1-day-old egg, revealing that such an early embryo sup...
متن کاملthe influence of social and cultural capital on efl students critical thinking skills
the major aim of this study was to investigate the relationship between social and cultural capital and efl students’ critical thinking skills. this study takes this relationship in to account to see if people with different sociocultural status are different regarding their critical thinking skills. to this end, 160 university students majoring in english language and literature, english trans...
15 صفحه اولCharacterization of chimpanzee/human monoclonal antibodies to vaccinia virus A33 glycoprotein and its variola virus homolog in vitro and in a vaccinia virus mouse protection model.
Three distinct chimpanzee Fabs against the A33 envelope glycoprotein of vaccinia virus were isolated and converted into complete monoclonal antibodies (MAbs) with human gamma 1 heavy-chain constant regions. The three MAbs (6C, 12C, and 12F) displayed high binding affinities to A33 (K(d) of 0.14 nM to 20 nM) and may recognize the same epitope, which was determined to be conformational and locate...
متن کاملMajor neutralizing sites on vaccinia virus glycoprotein B5 are exposed differently on variola virus ortholog B6.
Immunization against smallpox (variola virus) with Dryvax, a live vaccinia virus (VV), was effective, but now safety is a major concern. To overcome this issue, subunit vaccines composed of VV envelope proteins from both forms of infectious virions, including the extracellular enveloped virion (EV) protein B5, are being developed. However, since B5 has 23 amino acid differences compared with it...
متن کاملProtection against lethal vaccinia virus challenge in HLA-A2 transgenic mice by immunization with a single CD8+ T-cell peptide epitope of vaccinia and variola viruses.
CD8(+) T lymphocytes have been shown to be involved in controlling poxvirus infection, but no protective cytotoxic T-lymphocyte (CTL) epitopes are defined for variola virus, the causative agent of smallpox, or for vaccinia virus. Of several peptides in vaccinia virus predicted to bind HLA-A2.1, three, VETFsm(498-506), A26L(6-14), and HRP2(74-82), were found to bind HLA-A2.1. Splenocytes from HL...
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ژورنال
عنوان ژورنال: The Lancet
سال: 1854
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(02)40602-2