Influence of the drug distribution in electrospun gliadin fibers on drug-release behavior
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چکیده
منابع مشابه
Effects of drug solubility, state and loading on controlled release in bicomponent electrospun fibers.
Bicomponent fibers of two semi-crystalline (co)polymers, poly(varepsilon-caprolactone), and poly(oxyethylene-b-oxypropylene-b-oxyethylene), were obtained by electrospinning. Acetazolamide and timolol maleate were loaded in the fibers in different concentrations (below and above the drug solubility limit in polymer) in order to determine the effect of drug solubility in polymer, drug state, drug...
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The purpose of the present study was investigating kinetic and thermodynamic analysis using eudragit (EUD) polymer as controller to drug release mebendazole. nanofibers containing various proportions of EUD polymer, that were prepared with electrospinning technique. In this study, the amount of drug mebendazole release was investigated using nanofibers containing EUD at concentrations 50, 250,...
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This study was aimed at assessing the potential use of electrospun fibers as drug delivery vehicles with focus on the different diameters and drug contents to control drug release and polymer fiber degradation. A drug-loaded solvent-casting polymer film was made with an average thickness of 100 microm for comparative purposes. DSC analysis indicated that electrospun fibers had a lower T(g) but ...
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Electrospun fiber mats are currently gaining attention as advanced drug delivery systems. Dissolution testing for such systems is generally performed in small vials by immersing the fiber mats in buffered solutions. Defined aliquots of dissolution medium are withdrawn at predefined time points, and the dissolved drug is quantified. However, this procedure is associated with several drawbacks. T...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutical Sciences
سال: 2017
ISSN: 0928-0987
DOI: 10.1016/j.ejps.2017.06.017