Influence of sesamin on CYP 2C‐mediated diclofenac metabolism: in vitro and in vivo analysis
نویسندگان
چکیده
منابع مشابه
Influence of sesamin on CYP2C-mediated diclofenac metabolism: in vitro and in vivo analysis
Our previous studies revealed that sesamin caused a mechanism-based inhibition (MBI) of CYP2C9 in human liver microsomes. Additionally, we observed a similar MBI of CYP2C by sesamin in the rat liver microsomes. Sesamin-induced difference spectra of rat or human liver microsomes in the presence of NADPH showed a peak at 459 nm, suggesting the formation of a metabolic-intermediate (MI) complex of...
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ژورنال
عنوان ژورنال: Pharmacology Research & Perspectives
سال: 2015
ISSN: 2052-1707,2052-1707
DOI: 10.1002/prp2.174