Influence of 1,25-dihydroxy-vitamin D3 and Vitamin D3 analogs on keratinocyte growth and differentiation
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چکیده
منابع مشابه
20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation.
It has been shown that mammalian cytochrome P450scc can metabolize vitamin D3 to 20-hydroxyvitamin D3 (20(OH)D3) and 20,22(OH)2D3. To define the biological significance of this pathway, we tested the effects of 20(OH)D3 on the differentiation program of keratinocytes and on the expression of enzymes engaged in vitamin D3 metabolism. Immortalized HaCaT and adult human epidermal keratinocytes wer...
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Clouds are affected by aspects of climate change and are a major influencing factor on the pre-vitamin D3 effective solar UV (UVD3) exposures that humans receive. The aim of this research was to investigate the influence of clouds on the short wavelength cut-off of the spectral UVD3 irradiances, on the maximum of the UVD3 spectral irradiances and on the magnitude of the UVD3 irradiances. The sp...
متن کاملIn vitro cellular muscle calcium metabolism. Characterization of effects of 1,25-dihydroxy-vitamin D3 and 25-hydroxy-vitamin D3.
Cultures of vitamin D-deficient chick soleus muscle and 12 day-old chick embryo myoblasts were used to characterize the effects of 1,25-dihydroxy-vitamin D3 and 25-hydroxy-vitamin D3 on muscle cell Ca metabolism. Physiological amounts of both sterols increased the rate and extent of 45Ca uptake by cultures. However, 1,25(OH)2D3 was significantly more effective than 25 OHD3. The greater potency ...
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BACKGROUND In addition to the regulation of calcium homeostasis, vitamin D affects the cellular immune system, targets the TNF-alpha pathway and increases vasoconstrictor response to angiotensin II. We therefore examined the effect of 1,25-dihydroxy-vitamin D(3) on coagulation and organ failure in experimental sepsis in the rat. METHODS Three series of placebo-controlled studies were conducte...
متن کاملCD-ring modified vitamin D3 analogs and their superagonistic action.
Non-steroidal analogs of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] represent a most particular class of analogs because they are either not directly derived from the core 1,25(OH)2D3-structure or they have modifications in the core structure that are so drastic that the steroidal structure is lost. Non-steroidal CD-ring analogs of 1,25(OH)2D3 have been developed to study the role of the central ri...
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ژورنال
عنوان ژورنال: Acta Dermato-Venereologica
سال: 1999
ISSN: 0001-5555
DOI: 10.1080/000155599750011589