Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes
نویسندگان
چکیده
منابع مشابه
Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes.
Posttranslational modifications of self-proteins play a substantial role in the initiation or propagation of the autoimmune attack in several autoimmune diseases, but their contribution to type 1 diabetes is only recently emerging. In the current study, we demonstrate that inflammatory stress, induced by the cytokines interleukin-1β and interferon-γ, leads to citrullination of GRP78 in β-cells....
متن کاملCitrullinated glucose - regulated protein 78 is an autoantigen in type 1 diabetes . Running title : GRP 78 is an autoantigen in type 1 diabetes
Post-translational modifications of self-proteins play a substantial role in the initiation or propagation of the autoimmune attack in several autoimmune diseases, but their contribution to type 1 diabetes is only recently emerging. In the present study we demonstrate that inflammatory stress, induced by the cytokines IL-1β and IFNγ, leads to citrullination of GRP78 in beta-cells. This is coupl...
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Many cancer patients develop tumor-reactive immune responses against antigens that are either expressed on the surface of tumor cells or released from them into the peripheral circulation. In this study, tumor-reactive immunoglobulins, present in the sera of ovarian cancer patients, were used to identify commonly recognized tumor-associated antigens on ovarian tumor cells. Western immunoblot an...
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endoplasmic reticulum has a critical role in the synthesis and folding of secretory and membrane proteins. high accumulation of proteins in er activates the unfolded protein response and glucose regulated protein 78 or gpr78 plays an essential role in this pathway. unfolded protein response is activated in cancerous cells due to their adverse condition to survive and it has been shown that grp...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2018
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db18-0295