Inflammation and cardiorespiratory fitness in overweight women and men: the FATCOR study

Abstract Background Women have more body fat compared to men, and adipose tissue is associated with chronic inflammation. Cardiorespiratory fitness has on the other hand been postulated lower However, sex-specific associations of inflammation cardiorespiratory less studied. Purpose To assess inflammatory markers in overweight obese women men according FAT CardiOvasculaR dysfunction (FATCOR) study. Methods was assessed by maximal oxygen uptake (VO2max) cardiopulmonary exercise testing 566 subjects (mean age 48±9 years, 60% women) mass index (BMI) >27.0 kg/m2. Participants were grouped sex, status identified from sex specific VO2max thresholds. C-reactive protein (CRP) serum amyloid A (SAA) analysed using Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight spectrometry. Serum levels kynurenine:tryptophan ratio (KTR) pyriodoxic acid (PAr) measured liquid chromatography tandem All log transformed before inclusion linear regression analyses. Results In total study population, 63% had obesity 74% unfit. Unfit highest percentage CRP SAA groups (p<0.05), while KTR PAr higher only fit (p<0.05). multivariable analyses women, (β −0.15, p=0.001), −0.10, p=0.03) −0.09, after adjusting for age, percentage, hypertension metabolic syndrome. −0.14, p=0.02) adjusted (n=213), p=0.01) −0.13, remained VO2max, (n=144) there no significant between VO2max. Conclusion Among participating FATCOR study, unfit markers. The association reduced pronounced than particular when present. Funding Acknowledgement Type funding sources: Public grant(s) – National budget only. Main source(s): Western Regional Health Authority Norway