Inferring positive selection in humans from genomic data
نویسندگان
چکیده
منابع مشابه
Genomic regions exhibiting positive selection identified from dense genotype data.
The allele frequency spectrum of polymorphisms in DNA sequences can be used to test for signatures of natural selection that depart from the expected frequency spectrum under the neutral theory. We observed a significant (P = 0.001) correlation between the Tajima's D test statistic in full resequencing data and Tajima's D in a dense, genome-wide data set of genotyped polymorphisms for a set of ...
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Identifying targets of positive selection in humans has, until recently, been frustratingly slow, relying on the analysis of individual candidate genes. Genomics, however, has provided the necessary resources to systematically interrogate the entire genome for signatures of natural selection. To date, 21 genome-wide scans for recent or ongoing positive selection have been performed in humans. A...
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ژورنال
عنوان ژورنال: Investigative Genetics
سال: 2015
ISSN: 2041-2223
DOI: 10.1186/s13323-015-0023-1