منابع مشابه
Inferring fitness landscapes.
Since 1983, study of natural selection has relied heavily on multiple regression of fitness on the values for a set of traits via ordinary least squares (OLSs), as proposed by Lande and Arnold, to obtain an estimate of the quadratic relationship between fitness and the traits, the fitness surface. However, well-known statistical problems with this approach can affect inferences about selection....
متن کاملInferring fitness landscapes by regression produces biased estimates of epistasis.
The genotype-fitness map plays a fundamental role in shaping the dynamics of evolution. However, it is difficult to directly measure a fitness landscape in practice, because the number of possible genotypes is astronomical. One approach is to sample as many genotypes as possible, measure their fitnesses, and fit a statistical model of the landscape that includes additive and pairwise interactiv...
متن کاملFitness Landscapes
Fitness landscapes are a valuable concept in evolutionary biology, combinatorial optimization, and the physics of disordered systems. A fitness landscape is a mapping from a configuration space that is equipped with some notion of adjacency, nearness, distance or accessibility, into the real numbers. Landscape theory has emerged as an attempt to devise suitable mathematical structures for descr...
متن کاملClimbing Combinatorial Fitness Landscapes
Résumé en anglais Hill-climbing constitutes one of the simplest way to produce approximate solutions of a combinatorial optimization problem, and is a central component of most advanced metaheuristics. This paper focuses on evaluating climbing techniques in a context where deteriorating moves are not allowed, in order to isolate the intensification aspect of metaheuristics. We aim at providing ...
متن کاملB2.7.2 NK Fitness Landscapes
NK fitness landscapes are stochastically generated fitness functions on bit strings, parameterized (with genes and interactions between genes) so as to make them tunably ‘rugged’. Under the ‘natural’ genetic operators of bit-flipping mutation or recombination, NK landscapes produce multiple domains of attraction for the evolutionary dynamics. NK landscapes have been used in models of epistatic ...
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ژورنال
عنوان ژورنال: Evolution
سال: 2010
ISSN: 0014-3820
DOI: 10.1111/j.1558-5646.2010.01010.x