Inferring Clusters of Orthologous and Paralogous Transcripts

Abstract The alternative processing of eukaryote genes allows producing multiple distinct transcripts from a single gene, thereby contributing to the transcriptome diversity. Recent studies suggest that more than 90% human are concerned, and resulting highly conserved between orthologous genes. In this paper, we first present model define orthology paralogy relationships at level, then an algorithm infer clusters paralogous transcripts. Gene-level homology used different types Reciprocal Best Hits approach is isoorthologous recent We applied method gene families Ensembl-Compara database. results agreeing with those previous comparing also provide evidence searching for beyond will likely yield valuable information. obtained on available https://github.com/UdeS-CoBIUS/TranscriptOrthology . Supplementary material can be found https://doi.org/10.5281/zenodo.7750949