Infectious Disease-Related Applications

Microarray Applications in Infectious Disease

Modern biology and genomic sciences are rooted in infectious disease research. One of the earliest investigations into the biology of pneumococci led to the landmark 1944 discovery that genes are made of DNA and not protein. A half century later, inexpensive, reliable, and automated DNA sequencing methods have allowed scientists to sequence the complete genomes of nearly 2,000 different bacteri...

Phylodynamic applications in 21st century global infectious disease research

Background Phylodynamics, the study of the interaction between epidemiological and pathogen evolutionary processes within and among populations, was originally defined in the context of rapidly evolving viruses and used to characterize transmission dynamics. The concept of phylodynamics has evolved since the early 21st century, extending its reach to slower-evolving pathogens, including bacteri...

Evidence for infectious component of Hodgkin's disease and related considerations.

The four epidemiological approaches used to evaluate the hypothesis that Hodgkin's disease might have an infectious component are reviewed. The limitations of each approach are summarized and some related questions are raised. The emerging picture for Hodgkin's disease is that a variety of factors, both environmental and genetic, might be important in the etiology of this disorder.

Evidence for Infectious Component of Hodgkin's Disease and Related Considerations

The only et iological hypothesis for Hodgkin's disease that has been intensively pursued to date relates to its possible infectious nature. Recently, several investigators have evaluated the epidemiological (1,29) and immunological characteristics of this disorder t o determine whether they are consistent with this hypothesis. For example, Order and Hellman (21) have suggested that the cellular...

MRI follow-up of CF-related infectious lung disease