منابع مشابه
Limitation of enzymatic models for predicting myocardial infarct size.
The possibility of predicting myocardial infarct size from early enzyme measurements was studied using a physiological two compartment distribution model. Based on this the time dependent appearance function in plasma was calculated for creatine kinase, aspartate aminotransferase, and lactate dehydrogenase in 29 patients suffering from acute myocardial infarction. On average, the appearance fun...
متن کاملEffect of infarct size limitation by propranolol on ventricular arrhythmias after myocardial infarction.
These experiments show that pretreatment with propranolol was able to achieve significant infarct size reduction in this particular animal model of LAD occlusion followed by reperfusion through a critical stenosis. Despite infarct size reduction, the propranolol pretreatment prolonged the time course of spontaneous ventricular arrhythmias after acute myocardial infarction in the conscious dog. ...
متن کاملDoes myocardial stunning contribute to infarct size limitation by ischemic preconditioning?
BACKGROUND The mechanism through which ischemic preconditioning causes cardioprotection is unknown. The present study investigated the role of stunning in preconditioning. METHODS AND RESULTS We studied three different protocols of preconditioning: two cycles of 2-minute ischemia separated by 5-minute reperfusion (2'PC), one cycle of 5-minute ischemia by 5-minute reperfusion (5'PC1), and two ...
متن کاملLimitation of experimental myocardial infarct size by magnesium sulfate pre-treatment in dogs.
The present study was designed to evaluate the ability of magnesium sulfate (30 mg/kg, iv, 24 hr and 2 hr prior) to limit myocardial infarct size following permanent left coronary artery occlusion in adult mongrel dogs. Non-perfused myocardium which is the area at risk was visualised by injecting methylene blue intraatrially, 24 hr after coronary artery occlusion. The infarcted myocardium was v...
متن کاملLimitation of Infarct Size and No-Reflow by Intracoronary Adenosine Depends Critically on Dose and Duration.
OBJECTIVES In the absence of effective clinical pharmacotherapy for prevention of reperfusion-mediated injury, this study re-evaluated the effects of intracoronary adenosine on infarct size and no-reflow in a porcine model of acute myocardial infarction using clinical bolus and experimental high-dose infusion regimens. BACKGROUND Despite the clear cardioprotective effects of adenosine, when a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2002
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(02)02268-4