Inefficiency of haemodialysis in acute phenytoin intoxication.
نویسندگان
چکیده
منابع مشابه
Charcoal hemoperfusion for phenytoin intoxication.
Accidental ingestion of phenytoin can lead to severe neurological sequelae. Charcoal hemoperfusion decreases phenytoin levels but has never been reported before in children. We present a child with accidental ingestion of phenytoin who responded to charcoal hemoperfusion.
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Caffeine is the most widely consumed psychoactive substance worldwide. Intoxication causes central nervous system and haemodynamic complications, which have significant mortality rates. We report the case of a 39-year-old woman who ingested ∼0.5 mol (100 g) of pure caffeine, leading to a peak serum concentration of 2.95 mmol/L (574 mg/L). Three consecutive haemodialysis sessions caused serum ca...
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We describe a patient in whom phenytoin toxicity developed soon after treatment with parenteral miconazole. A 51 year old man was admitted for treatment of recurrent severe haemoptysis associated with pulmonary aspergillosis. He was in chronic respiratory failure. He was a non-smoker. Biochemical 'indices of liver function were normal. There was a past history of asthma and also of epilepsy for...
متن کاملPhenytoin intoxication during concurrent diazepam therapy.
Phenytoin elimination is a saturable process obeying Michaelis-Menten kinetics. Plasma phenytoin levels are not related linearly to dose, and small changes in enzyme activity produced by concurrent drug therapy could alter plasma levels. Two cases of phenytoin intoxication associated with simultaneous administration of diazepam are reported. Intravenous phenytoin infusions were given and the ap...
متن کاملPhenytoin Intoxication: Burden and risk factors.
OBJECTIVE The aim of the study is to determine: 1) the frequency of patients admitted for phenytoin toxicity and their economic burden; 2) the clinical symptoms and signs of intoxication; 3) the causes or risk factors of intoxication, and 4) the ways to prevent phenytoin toxicity. METHODS Retrospective review of hospital ICD coded database between 1987 and 1998. All patients with phenytoin in...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1979
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1979.tb00955.x