Industrializing a Bacterial Strain forl-Serine Production through Translation Initiation Optimization
نویسندگان
چکیده
منابع مشابه
Fidelity of bacterial translation initiation: a stochastic kinetic model
During the initiation stage of protein synthesis, a ribosomal initiation complex (IC) is assembled on a messenger RNA (mRNA) template. In bacteria, the speed and accuracy of this assembly process are regulated by the complementary activities of three essential initiation factors (IFs). Selection of an authentic N-formylmethionyl-transfer RNA (fMet-tRNA) and the canonical, triplet-nucleotide mRN...
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Studies in pro- and eukaryotes have revealed that translation can determine the stability of a given messenger RNA. In bacteria, intrinsic mRNA signals can confer efficient ribosome binding, whereas translational feedback inhibition or environmental cues can interfere with this process. Such regulatory mechanisms are often controlled by RNA-binding proteins, small noncoding RNAs and structural ...
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ژورنال
عنوان ژورنال: ACS Synthetic Biology
سال: 2019
ISSN: 2161-5063,2161-5063
DOI: 10.1021/acssynbio.9b00169