Induction of Hypersensitivity to a Previously Tolerated Antiepileptic Drug by a Second Antiepileptic Drug

A new antiepileptic drug.

Stiripentol. A novel antiepileptic drug.

Epilepsy is one of the most widespread pathologies of human brain, affecting approximately 1% of world population. Despite the development of new methods of seizure control, chronic administration of antiepileptic drugs (AEDs) remains the treatment of choice. Nevertheless, pharmacotherapy is not always effective. In the case of single drug treatment, the number of non-responding patients is as ...

Antiepileptic drug actions.

Antiepileptic drugs (AEDs) vary in their efficacy against generalized tonic-clonic, myoclonic, and absence seizures, suggesting different mechanisms of action. Phenytoin (PHT), carbamazepine (CBZ), and valproate (VPA) reduced the ability of mouse central neurons to sustain high-frequency repetitive firing of action potentials (SRF) at therapeutic free serum concentrations. Phenobarbital (PB) an...

Solid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug

Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...

Antiepileptic drug monitoring.

Normal and Abnornml De the Human Nervous Syste Lemire, J. D. Loeser, R. VN -.E. C. Alvord. (Pp. 421 $27.50.) Harper and Row USA. 1975. 'Fills a long-felt gap' is a viewers but the phrase is ii this book. In a clear an way it gathers together a of information about the and growth of the hun system and gives a brief the major developmental Standardised graphs pres formation in a manner rapid refe...