Induction of Fos protein immunoreactivity by spinal cord contusion

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Induction of Fos protein immunoreactivity by spinal cord contusion.

The objective of the present study was to identify neurons in the central nervous system that respond to spinal contusion injury in the rat by monitoring the expression of the nuclear protein encoded by the c-fos gene, an activity-dependent gene, in spinal cord and brainstem regions. Rats were anesthetized with urethane and the injury was produced by dropping a 5-g weight from 20.0 cm onto the ...

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Previous experiments have shown that noxious stimulation increases expression of the c-fos proto-oncogene in subpopulations of spinal cord neurons. c-fos expression was assessed by immunostaining for Fos, the nuclear phosphoprotein product of the c-fos gene. In this study, we examined the effect of systemic morphine on Fos-like immunoreactivity (FLI) evoked in the formalin test, a widely used m...

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ژورنال

عنوان ژورنال: Brazilian Journal of Medical and Biological Research

سال: 2000

ISSN: 0100-879X

DOI: 10.1590/s0100-879x2000000500006