Induction of antitumor response to fibrosarcoma by Newcastle disease virus-infected tumor vaccine
نویسندگان
چکیده
منابع مشابه
Induction of antitumor response to fibrosarcoma by Newcastle disease virus-infected tumor vaccine
Fibrosarcoma is a locally aggressive malignant tumor with a high recurrence rate, so that wide excisional surgery is necessary for treatment. However, it is often difficult to resect with a sufficient margin of excision at the site of tumor infiltration. Recombinant tumor vaccine therapy is a useful method to induce specific immunity. In this study, we have shown its utility as a candidate for ...
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A new recombinant (rec) Newcastle disease virus (NDV) with incorporated human interleukin 2 (IL-2) as foreign therapeutic gene [rec(IL-2)] will be described. The foreign gene in rec(IL-2) did not affect the main features of NDV replication nor its tumor selectivity. Biologically active IL-2 was produced in high amounts by tumor cells infected with rec(IL-2). Tumor vaccine cells infected by rec(...
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ژورنال
عنوان ژورنال: Medical Oncology
سال: 2017
ISSN: 1357-0560,1559-131X
DOI: 10.1007/s12032-017-1034-y