Induction of Antigen-Specific Th1-Type Immune Responses by Gamma-Irradiated Recombinant Brucella abortus RB51
نویسندگان
چکیده
منابع مشابه
Induction of antigen-specific Th1-type immune responses by gamma-irradiated recombinant Brucella abortus RB51.
Brucella abortus strain RB51 is an attenuated rough mutant used as the live vaccine against bovine brucellosis in the United States and other countries. We previously reported the development of strain RB51 as a bacterial vaccine vector for inducing Th1-type immune responses against heterologous proteins. Because safety concerns may preclude the use of strain RB51-based recombinant live vaccine...
متن کاملBrucella abortus strain RB51 as a vector for heterologous protein expression and induction of specific Th1 type immune responses.
Brucella abortus strain RB51 is a stable, rough, attenuated mutant widely used as a live vaccine for bovine brucellosis. Our ultimate goal is to develop strain RB51 as a preferential vector for the delivery of protective antigens of other intracellular pathogens to which the induction of a strong Th1 type of immune response is needed for effective protection. As a first step in that direction, ...
متن کاملImmune responses of bison and efficacy after booster vaccination with Brucella abortus strain RB51.
Thirty-one bison heifers were randomly assigned to receive saline or a single vaccination with 10(10) CFU of Brucella abortus strain RB51. Some vaccinated bison were randomly selected for booster vaccination with RB51 at 11 months after the initial vaccination. Mean antibody responses to RB51 were greater (P < 0.05) in vaccinated bison after initial and booster vaccination than in nonvaccinated...
متن کاملImmune responses and safety after dart or booster vaccination of bison with Brucella abortus strain RB51.
One alternative for management of brucellosis in Yellowstone National Park bison (Bison bison) is vaccination of calves and yearlings. Although Brucella abortus strain RB51 vaccination protects bison against experimental challenge, the effect of booster vaccinations was unknown. This study characterized immunologic responses after dart or booster vaccination of bison with Brucella abortus strai...
متن کاملImmune Response of Calves Vaccinated with Brucella abortus S19 or RB51 and Revaccinated with RB51
Brucella abortus S19 and RB51 strains have been successfully used to control bovine brucellosis worldwide; however, currently, most of our understanding of the protective immune response induced by vaccination comes from studies in mice. The aim of this study was to characterize and compare the immune responses induced in cattle prime-immunized with B. abortus S19 or RB51 and revaccinated with ...
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ژورنال
عنوان ژورنال: Clinical and Vaccine Immunology
سال: 2005
ISSN: 1556-6811,1556-679X
DOI: 10.1128/cdli.12.12.1429-1436.2005