Induction of a protective capsular polysaccharide antibody response to a multiepitope DNA vaccine encoding a peptide mimic of meningococcal serogroup C capsular polysaccharide
نویسندگان
چکیده
منابع مشابه
Pneumococcal Capsular Polysaccharide Vaccine
Streptococcus pneumoniae (pneumococcus [Pnc]) is a common bacterial agent found in mild mucosal as well as severe systemic infections. Local infections, such as acute otitis media, are rather common; every child has at least one during the first 2 years of life (1), and Pnc is the causative agent in approximately half of the bacterial culturepositive cases (2). Pneumonia is another disease ofte...
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Submit Manuscript | http://medcraveonline.com Abbreviations: BSA: Bovine Serum Albumin; CD4: Cluster of Differentiation 4; CPS: Capsular Polysaccharide; CXCL10: Chemokine X Chemotactic Ligand 10; DHBA: Dihydroxybenzoic Acid; ER Stress: Endoplasmic Reticulum Stress; FBS: Fetal Bovine Serum; HLA: Human Leukocyte Antigen; IP-10: InterferonInducible Protein 10; LCN2: Lipocalin 2; NGAL: NeutrophilGe...
متن کاملA peptide mimotope of type 8 pneumococcal capsular polysaccharide induces a protective immune response in mice.
Increasing antibiotic resistance and a rising patient population at risk for infection due to impaired immunity underscore the importance of vaccination against pneumococci. However, available capsular polysaccharide vaccines are often poorly immunogenic in patients at risk for pneumococcal disease. The goal of this study was to explore the potential of peptide mimotopes to function as alternat...
متن کاملMeningococcal polysaccharide vaccine failure in a patient with C7 deficiency and a decreased anti-capsular antibody response.
A 20-y-old male presented with symptoms of meningococcal sepsis and died despite appropriate medical interventions. Blood cultures grew N. meningitidis serogroup Y. The patient had received the meningococcal quadrivalent (A,C,W-135,Y) polysaccharide vaccine 15 mo previously. Because the patient had a history of meningococcal meningitis at age 10, archived serum was obtained for further analysis...
متن کاملStudy of various presentation forms for a peptide mimetic of Neisseria meningitidis serogroup B capsular polysaccharide.
The formulation of a broadly protective vaccine to prevent the serogroup B Neisseria meningitidis (MenB) disease is still an unmet medical need. We have previously reported the induction of bactericidal and protective antibodies against MenB after immunization of mice with a phage-displayed peptide named 4 L-5. This peptide mimics a capsular polysaccharide (CPS) epitope in MenB. With the aim of...
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ژورنال
عنوان ژورنال: Immunology
سال: 2003
ISSN: 0019-2805,1365-2567
DOI: 10.1046/j.1365-2567.2003.01732.x