Inducible Adeno-Associated Virus-Mediated IL-2 Gene Therapy Prevents Autoimmune Diabetes
نویسندگان
چکیده
منابع مشابه
Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes.
IL-2 and TGF-β1 play key roles in the immunobiology of Foxp3-expressing CD25(+)CD4(+) T cells (Foxp3(+)Treg). Administration of these cytokines offers an appealing approach to manipulate the Foxp3(+)Treg pool and treat T cell-mediated autoimmunity such as type 1 diabetes. However, efficacy of cytokine treatment is dependent on the mode of application, and the potent pleiotropic effects of cytok...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2011
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1001422