Induced Pluripotency for Translational Research
نویسندگان
چکیده
منابع مشابه
Induced Pluripotency for Translational Research
The advent of induced pluripotent stem cells (iPSCs) has revolutionized the concept of cellular reprogramming and potentially will solve the immunological compatibility issues that have so far hindered the application of human pluripotent stem cells in regenerative medicine. Recent findings showed that pluripotency is defined by a state of balanced lineage potency, which can be artificially ins...
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The maintenance of pluripotency relies on an intricate transcriptional network hinged on a key set of transcription factors. Pluripotent stem cells have been shown to be sensitive to modulations of the cellular abundance and transcriptional activity of these key pluripotency factors. Recent evidence highlights the important role of post-translational modifications, including ubiquitination, sum...
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The stress-induced hyperthermia (SIH) response is the transient change in body temperature in response to acute stress. This body temperature response is part of the autonomic stress response which also results in tachycardia and an increased blood pressure. So far, a SIH response has been found in a variety of species (including rodents, baboons, turtles, pigs, impalas and chimpanzees), and th...
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S omatic cells derived from differentiated tissues can be reprogrammed back to a pluripotent state. However, multiple barriers exist to prevent such extreme dedifferentiation from occurring in vivo, which explains the inefficient induction of pluripotency by ectopic coexpression of Oct4, Sox2, Klf4, and c-Myc (OSKM) in somatic cells. In PNAS, Ganier et al. (1) report a method that uses frog egg...
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ژورنال
عنوان ژورنال: Genomics, Proteomics & Bioinformatics
سال: 2013
ISSN: 1672-0229
DOI: 10.1016/j.gpb.2013.08.001