Induced and thymus‐derived F oxp3 + regulatory T cells share a common niche
نویسندگان
چکیده
منابع مشابه
Human in vitro induced T regulatory cells and memory T cells share common demethylation of specific FOXP3 promoter region
BACKGROUND The FOXP3 gene is the master regulator for T regulatory cells and is under tight DNA methylation control at the Treg specific demethylated region (TSDR) in its first intron. This said, methylation of its promoter region, the significance of which is unknown, has also been associated with various immune-related disease states such as asthma, food allergy, auto-immunity and cancer. Her...
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Results from studies comparing the diversity and specificity of the TCR repertoires expressed by conventional (Tconv) and regulatory (Treg) CD4+ T cell have varied depending on the experimental system employed. We developed a new model in which T cells express a single fixed TCRα chain, randomly rearranged endogenous TCRβ chains, and a Foxp3-GFP reporter. We purified CD4+Foxp3- and CD4+Foxp3+ c...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2013
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.201343463