Individuals co-exposed to sand fly saliva and filarial parasites exhibit altered monocyte function

Sand fly saliva: toward a vaccine against leishmaniases

Leishmaniases are a group of sand fly-borne diseases caused by protozoan parasites from species of Leishmania genus. These diseases are reported in about 100 countries with a prevalence of 12 million people infected and incidence of 2 million people per year, putting approximately 350 million people at risk of the infections. Leishmaniases are endemic and are considered as important public heal...

Sand fly saliva & host immune response

Sand-Fly Saliva-Leishmania-Man: The Trigger Trio

Leishmaniases are worldwide diseases transmitted to the vertebrate host by the bite of an infected sand-fly. Sand-fly biting and parasite inoculation are accompanied by the injection of salivary molecules, whose immunomodulatory properties are actively being studied. This mini review focuses on how the interactions between sand-fly saliva and the immune system may shape the outcome of infection...

sand fly saliva: toward a vaccine against leishmaniases

leishmaniases are a group of sand fly-borne diseases caused by protozoan parasites from species of leishmania genus. these diseases are reported in about 100 countries with a prevalence of 12 million people infected and incidence of 2 million people per year, putting approximately 350 million people at risk of the infections. leishmaniases are endemic and are considered as important public heal...

Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania

BACKGROUND Leishmaniases are parasitic diseases present worldwide that are transmitted to the vertebrate host by the bite of an infected sand fly during a blood feeding. Phlebotomine sand flies inoculate into the mammalian host Leishmania parasites embedded in promastigote secretory gel (PSG) with saliva, which is composed of a diverse group of molecules with pharmacological and immunomodulator...