Indirect comparisons of competing interventions

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Indirect comparisons of competing interventions.

OBJECTIVES To survey the frequency of use of indirect comparisons in systematic reviews and evaluate the methods used in their analysis and interpretation. Also to identify alternative statistical approaches for the analysis of indirect comparisons, to assess the properties of different statistical methods used for performing indirect comparisons and to compare direct and indirect estimates of ...

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Indirect comparisons of therapeutic interventions

HEALTH POLITICAL BACKGROUND The comparison of the effectiveness of health technologies is not only laid down in German law (Social Code Book V, § 139 and § 35b) but also constitutes a central element of clinical guidelines and decision making in health care. Tools supporting decision making (e. g. Health Technology Assessments (HTA)) are therefore in need of a valid methodological repertoire fo...

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Inconsistency between direct and indirect comparisons of competing interventions: meta-epidemiological study

OBJECTIVE To investigate the agreement between direct and indirect comparisons of competing healthcare interventions. DESIGN Meta-epidemiological study based on sample of meta-analyses of randomised controlled trials. Data sources Cochrane Database of Systematic Reviews and PubMed. Inclusion criteria Systematic reviews that provided sufficient data for both direct comparison and independent i...

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Validity of indirect comparison for estimating efficacy of competing interventions: empirical evidence from published meta-analyses.

OBJECTIVE To determine the validity of adjusted indirect comparisons by using data from published meta-analyses of randomised trials. DESIGN Direct comparison of different interventions in randomised trials and adjusted indirect comparison in which two interventions were compared through their relative effect versus a common comparator. The discrepancy between the direct and adjusted indirect...

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Danger ahead: watch out for indirect comparisons!

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ژورنال

عنوان ژورنال: Health Technology Assessment

سال: 2005

ISSN: 1366-5278,2046-4924

DOI: 10.3310/hta9260