Increased startle potentiation to unpredictable stressors in alcohol dependence: Possible stress neuroadaptation in humans.
نویسندگان
چکیده
منابع مشابه
Increased startle potentiation to unpredictable stressors in alcohol dependence: Possible stress neuroadaptation in humans.
Stress plays a key role in addiction etiology and relapse. Rodent models posit that following repeated periods of alcohol and other drug intoxication, compensatory allostatic changes occur in the central nervous system (CNS) circuits involved in behavioral and emotional response to stressors. We examine a predicted manifestation of this neuroadaptation in recently abstinent alcohol-dependent hu...
متن کاملProbing for Neuroadaptations to Unpredictable Stressors in Addiction: Translational Methods and Emerging Evidence.
Stressors clearly contribute to addiction etiology and relapse in humans, but our understanding of specific mechanisms remains limited. Rodent models of addiction offer the power, flexibility, and precision necessary to delineate the causal role and specific mechanisms through which stressors influence alcohol and other drug use. This review describes a program of research using startle potenti...
متن کاملA systems approach to stress, stressors and resilience in humans
The paper focuses on the biology of stress and resilience and their biomarkers in humans from the system science perspective. A stressor pushes the physiological system away from its baseline state toward a lower utility state. The physiological system may return toward the original state in one attractor basin but may be shifted to a state in another, lower utility attractor basin. While some ...
متن کاملClinical Laboratory Stressors Used to Study Alcohol–Stress Relationships
Understanding the biologic systems that underlie the relationship between stress and alcohol consumption may lead to better prevention efforts and more effective treatments for alcoholism. Clinical laboratory studies offer a unique opportunity to examine these relationships by using a controlled environment to study how an acute stressor affects alcohol drinking and alcohol craving, how individ...
متن کاملBehavioral Neuroadaptation to Alcohol: From Glucocorticoids to Histone Acetylation
A prime mechanism that contributes to the development and maintenance of alcoholism is the dysregulation of the hypothalamic-pituitary-adrenal axis activity and the release of glucocorticoids (cortisol in humans and primates, corticosterone in rodents) from the adrenal glands. In the brain, sustained, local elevation of glucocorticoid concentration even long after cessation of chronic alcohol c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Abnormal Psychology
سال: 2017
ISSN: 1939-1846,0021-843X
DOI: 10.1037/abn0000265