Increased sensitivity of lateral flow immunoassay for ochratoxin A through silver enhancement

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Increased sensitivity of lateral flow immunoassay for ochratoxin A through silver enhancement.

Silver nucleation on gold has been exploited for signal amplification and has found application in several qualitative and quantitative bio-sensing techniques, thanks to the simplicity of the method and the high sensitivity achieved. Very recently, this technique has been tentatively applied to improve the performance of gold-based immunoassays. In this work, the exploitation of the signal ampl...

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A silver nanoparticle (AgNP)-based fluorescence-quenching lateral flow immunoassay with competitive format (cLFIA) was developed for sensitive detection of ochratoxin A (OTA) in grape juice and wine samples in the present study. The Ru(phen) 3 2 + -doped silica nanoparticles (RuNPs) were sprayed on the test and control line zones as background fluorescence signals. The AgNPs were designed as th...

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ژورنال

عنوان ژورنال: Analytical and Bioanalytical Chemistry

سال: 2013

ISSN: 1618-2642,1618-2650

DOI: 10.1007/s00216-013-7428-6