Increased mean arterial pressure goals after spinal cord injury and functional outcome

Intraspinal pressure and spinal cord perfusion pressure predict neurological outcome after traumatic spinal cord injury.

Imatinib Enhances Functional Outcome after Spinal Cord Injury

We investigated whether imatinib (Gleevec®, Novartis), a tyrosine kinase inhibitor, could improve functional outcome in experimental spinal cord injury. Rats subjected to contusion spinal cord injury were treated orally with imatinib for 5 days beginning 30 minutes after injury. We found that imatinib significantly enhanced blood-spinal cord-barrier integrity, hindlimb locomotor function, senso...

age-associated changes on axonal regeneration and functional outcome after spinal cord injury in rats.

this study was conducted to evaluate the association between aging and regenerative potential of spinal cord injury. three groups of male sprague-dawley rats, including young (40 days), mature (5-6 months) and old (28-29 months) were spinally hemisected at the l1 level. the locomotor performance was assessed weekly for eight weeks after lesion using locomotors' rating scale developed by basso, ...

Influence of Sexuality in Functional Recovery after Spinal Cord Injury in rats

  Background: Spinal cord injury (SCI) is a major clinical condition and research is commonly done to find suitable treatment options. However, there are some degrees of spontaneous recovery after SCI and gender is said to be a contributing factor in recovery, but this is controversial. This study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord inj...

Functional independence and rehabilitation outcome in traumatic spinal cord injury.

The purpose of this study was to investigation functional independence and rehabilitation outcomes of traumatic spinal cord patients. The data were obtained for 38 patients with traumatic spinal cord lesions admitted to the physical therapy unit from 1997 to 2001. The mean age was 32 +/- 6.48 years. Functional improvement was presented in terms of progress in independence in six daily activitie...